How would you treat metastatic squamous cell carcinoma arising from a mature cystic ovarian teratoma?

There is a lack of established guidelines to treat patients with metastatic squamous cell carcinoma arising from a mature cystic ovarian teratoma (MCT-SCC). In the absence of a clinical trial, this patient should be offered platinum-based chemotherapy. Next generation sequencing (NGS) should also be performed in an effort to identify a targetable genomic alteration. Given reports of rapid recurrence, chemotherapy should not be delayed while awaiting results of NGS. A treatment regimen with manageable toxicities is preferred, particularly in light of her poor prognosis and lack of data suggesting superior outcomes with more toxic platinum-based regimens. I favor carboplatin-paclitaxel over other reported active regimens such as TIP (Cisplati...