How would you treat recurrent endometrial carcinoma with a presentation of inguinal and external iliac adenopathy?

Topics: Radiation Oncology • Gynecologic Cancers • Endometrial Cancer • recurrence

Re-staging is otherwise negative; patient's disease has FIGO grade 1 endometroid histology

Answer from: Radiation Oncologist at Community Practice

I would treat with definitive intent with either surgery followed by (chemo) RT or definitive (chemo) RT targeting the pelvic at least up to the common iliac and bilateral inguinal region.

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Radiation Oncologist at Radiation Oncologists PC
If the PET shows no involvement outside the lymph ...

Answer from: Radiation Oncologist at Academic Institution

Presumable post-surgical recurrence without receipt of previous RT. Is there a vaginal recurrence as well in or extending to the distal vagina, which could explain the inguinal nodes? Are the nodes PET-positive or biopsy-proven? If this is purely a nodal recurrence, no reason to think distal vagina...

Answer from: Radiation Oncologist at Community Practice

If not already done, I would get PET/MRI and do an EUA with gyn onc to rule out vaginal recurrence as @Ashwin Shinde noted. Then I would treat with definitive intent RT with chemo if able. I would follow that with carbo taxol if tolerable +- IO with consideration of MMR status.

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