Topics:
Gynecologic Cancers • Targeted therapies
How would you treat refractory diarrhea in a patient with low grade serous ovarian cancer treated with Trametinib?
Literature regarding treatment of diarrhea due to Trametinib is limited and does not address safety of Lomotil.
Trametinib is known to cause significant diarrhea with 43% of patients affected with grade 1 or 2 diarrhea in phase II/III trials1. The recently released abstract for NRG-GOG 0281 reported on progression-free and overall survival, as well as toxicities related to use of Trametinib versus standard of...
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