How would you treat refractory diarrhea in a patient with low grade serous ovarian cancer treated with Trametinib?
Literature regarding treatment of diarrhea due to Trametinib is limited and does not address safety of Lomotil.
1 Answer
Mednet Member
Gynecologic Oncology · Novant Health New Hanover Regional Medical Center
Answered on
Trametinib is known to cause significant diarrhea with 43% of patients affected with grade 1 or 2 diarrhea in phase II/III trials1. The recently released abstract for NRG-GOG 0281 reported on progression-free and overall survival, as well as toxicities related to use of Trametinib versus standard of...
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