Register
Community
Overview
Experts
Editors
Fellows
Code of conduct
Company
About Us
FAQs
Privacy Policy
Terms of Use
Careers
Programs
News
News Releases
Press Coverage
Publications
Blog
Contact Us
Sign in
Topics:
Sarcoma
•
Medical Oncology
•
Cancer of Unknown Primary
How would you treat someone with unknown primary metastatic SMARCA4 deficient tumor (high-grade tumor with rhabdoid morphology)?
Answer from: Medical Oncologist at Community Practice
Ponatinib might be useful. You might also see if a clinical trial is available.http://clincancerres.aacrjournals.org/content/24/8/1932
Sign in or Register to read more
Answer from: Medical Oncologist at Academic Institution
Consider tazemetostat (epigenetic modifier via EZH2 nhibition) via compassionate use program.
Sign in or Register to read more
5664
5676
Related Questions
Can you use NGS panels or ctDNA to help you find organ of origin in the workup of carcinoma of unknown origin?
How do you sequence treatment for a patient following R2 resection of a large extremity leiomyosarcoma who has small lung nodules concerning for metastatic disease, but not yet biopsy proven?
How do you approach a patient with newly diagnosed high-grade osteosarcoma who received maximum cumulative dose of doxorubicin for a soft tissue sarcoma 10 years earlier?
How do you approach patients with lymph node positive osteosarcoma of the extremities for neoadjuvant chemotherapy?
How would you treat a patient with a locally recurrent myxofibrosarcoma, FNCLCC grade 2, that has recurred after multiple resections and radiotherapy?
How do you approach a well controlled HIV patient with diffuse cutaneous kaposi sarcoma who failed to respond to radiation, paclitaxel and monthly liposomal doxorubicin?
How do you approach a patient with undifferentiated pleomorphic sarcoma encasing the spinal cord post radiation for neurological deficits for further management?
When would you ever consider lifelong imatinib in adjuvant therapy for GIST?
How would you approach patients with primary cardiac sarcomas for adjuvant systemic treatment?
How do you approach patients with osteosarcoma of the maxilla for neoadjuvant chemotherapy?