How would you treat stage II pediatric type follicular lymphoma that is not amenable to surgical resection in an adolescent and young adult patient?

PTFL is recently distinguished as a distinct histopathological and clinical entity in the 2016 WHO Classification of Hematopoietic and Lymphoid Tissues. As such, previous reviews of pediatric follicular lymphomas include patients with other types of NHL which do not meet the definition. The best review of this, that I know of, is a chapter by Andishe Attarbaschi in O. Abla, A. Attarbaschi (eds.), Non-Hodgkin’s Lymphoma in Childhood and Adolescence, Springer Nature Switzerland AG 2019. It notes that a 2013 review of children with all subtypes of follicular NHL showed an excellent outcome with a watch and wait approach for completely resected stage 1 and chemotherapy for stage 2 patients, primarily NHL-BFM therapy. It can be assumed that many...