How would you treat Stage III unresectable adenocarcinoma of the lung with a BRAF-V600E mutation?

At this time, I do not think there is any role for BRAF directed therapy in patients with stage III unresectable adenocarcinoma. The standard of care remains chemoradiation followed by durvalumab. There is no evidence to support doing anything else. Unlike EGFR, for instance, where the use of consol...

At this time, I will still incorporate PACIFIC regimen in the treatment plan.