How would you work up a mildly neutropenic patient (ANC >800) with family history of neutropenia and personal history of occasional mouth sore?

Topics: Pediatric Oncology • Medical Oncology • Hematology • Bone Marrow Failure • Pediatric Hematology • Neutropenia

What are indications to order gene mutation studies (e.g. ELANE) and how would it help the patient?

Answer from: at Community Practice

The first question is whether to evaluate the neutropenia at all. With ANCs >800 and only occasional mouth sores, is a diagnosis necessary, and should the term “neutropenia” be used at all? If the family’s origin is in a part of the world where the Duffy null phenotype is common...

Comments

Medical Oncologist at Wentworth Douglass Hospital
Dr. @Peter Newburger, what are the further steps i...

at UMass Chan Medical School
The best answer is to refer to a hematologist expe...

Medical Oncologist at Wentworth Douglass Hospital
Thank you for the detailed reply!

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