How would you work up a patient with cutaneous mastocytosis?
Is a BM biopsy a must when there is skin involvement?
If tryptase level is mildly elevated but less than 20 would you recommend a BM biopsy?
2 Answers
Mednet MemberInvited Expert
Medical Oncology · Vanderbilt University Medical Center
Answered on
Is a BM biopsy a must when there is skin involvement?
I think a bone marrow biopsy for cutaneous mastocytosis is most helpful when it is in the setting of a patient being referred by dermatology for a skin biopsy result showing TMEP (telangiectasia macularis eruptive perstans) since TMEP has been ...
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Mednet MemberInvited Expert
Dermatology · Duke Health
Answered on · Updated on
In adults, consider mastocytosis as being systemic until you prove it is not. A single normal or low-elevated tryptase does not eliminate the possibility of systemic mastocytosis. All patients should go to Heme/Onc for consideration of bone marrow biopsy and ideally high-sensitivity PCR to look for ...
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