If a patient is unable to tolerate one CDK 4/6 inhibitor, do you switch to a different one?

If a patient is unable to tolerate one CDK 4/6 inhibitor, do you switch to a different one?

• Yes, once all standard dose reductions have been attempted, will trial an alternate CDK4/6i for any toxicity issues
• Yes, once first dose reduction has been attempted, will trial an alternate CDK4/6i for any toxicity issues
• Only if toxicity is limited to cytopenias
• Only if toxicity is limited to cutaneous/dermatologic effects
• Only if toxicity is limited to other nonhematologic/noncutaneous toxicity
• No, once dose reductions are attempted I typically switch class rather than trial an alternate CDK4/6i
• Other