If a stage I laryngeal cancer completely responds to FU-based chemotherapy (given for another malignancy) would you consider observation?

We expect a 60-80% response rate with induction chemo data, with 20% having a complete response. That doesn’t preclude local treatment but predicts for better outcome.

Holding RT and following early stage laryngeal cancer seems like a risky proposition. You have a high likelihood of a favorable outcome with microscopic residual disease treated with small field definitive radiotherapy. The late toxicities are low with RT for early glottic cancer and it’s a relative...

2025-12-04 Addendum: Additional long term data from MDAH on CTX alone in Stage II-IVa laryngeal SqCCa. Ref. below.

Trinconi Cunha, M et al. Chemotherapy Alone for Stage II-IVa laryngeal squamous cell carcinoma: A 20-year follow up. Cancer 2025;131(23)

2019-03-03 Addendum: 10 yr update of Univ. Paris ...

No. I would irradiate. Jim Parsons (UF alumni) used to say a "CR is only halfway to a C-U-R-E."