If a stage I laryngeal cancer completely responds to FU-based chemotherapy (given for another malignancy) would you consider observation?
We expect a 60-80% response rate with induction chemo data, with 20% having a complete response. That doesn’t preclude local treatment but predicts for better outcome.
Holding RT and following early stage laryngeal cancer seems like a risky proposition. You have a high likelihood of a favorable outcome with microscopic residual disease treated with small field definitive radiotherapy. The late toxicities are low with RT for early glottic cancer and it’s a relative...
2025-12-04 Addendum: Additional long term data from MDAH on CTX alone in Stage II-IVa laryngeal SqCCa. Ref. below.
Trinconi Cunha, M et al. Chemotherapy Alone for Stage II-IVa laryngeal squamous cell carcinoma: A 20-year follow up. Cancer 2025;131(23)
2019-03-03 Addendum: 10 yr update of Univ. Paris ...