Topics:
Radiation Oncology • Gastrointestinal Cancers
If technically feasible, would you consider SBRT for locally recurrent ampullary carcinoma in an inoperable radiation naive patient?
Or would you always aim to treat with combined chemotherapy and fractionated radiation?
Answer from: Radiation Oncologist at Academic Institution
No. A stereotactic technique cannot improve outcome when the duodenum cannot be avoided. As in every ampullary cancer I have ever treated, you are limited to palliative doses by the tolerance of the mucosa. Larger doses per fraction only serve to narrow the therapeutic index and use up tolerance bas...
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