In 2024, do you consider isolated gain(1q) [not amp(1q)] to be a high-risk cytogenetic abnormality in multiple myeloma?

The brief answer from my standpoint is that some patients with 1q gain will have their disease behave high-risk and some will not.

The longer answer...

As the question alludes to, the presence of high-risk cytogenetic abnormalities and 1q gain should be considered high-risk (or even ultra high-risk)....