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In a germline BRCA2 positive pt with NSCLC after chemoIO frontline and taxotere as a second line, would you consider PARP inhibitors?

If so, would you combine them vs monotherapy? Patient ECOG is 1
1 Answer
Mednet Member
Mednet MemberInvited Expert
Medical Oncology · Adena Cancer Center
Answered on

This is a challenging situation and one I have encountered in clinic. The data for PARP inhibitors in NSCLC is limited. There have been limited trials for this specific population including NSCLC so I have extrapolated from the breast/ovarian experience.

For instance, there was a phase II clinical ...

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