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In a patient with metastatic breast cancer who has progressed on multiple medications and has now developed multiple brain metastases, what is your radiotherapy plan if the patient is taking sacituzumab govitecan?

Does this affect your dose/fractionation? Or are you safe treating concurrently?
1 Answer
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Radiation Oncology · Varian Medical Systems/Allegheny health network
Answered on

The limited published data have not shown increased complications with SRS along with sacituzumab, unlike increased necrosis seen with HER2/neu antibody conjugate.

Khatri et al., PMID 41026418

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