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In a patient with cardiac comorbidities, who meets ASTRO APBI criteria other than a positive margin, would you offer APBI in an attempt to reduce cardiac dose?

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Would you recommend partial breast irradiation for young woman who fits ASTRO criteria except for positive margin at left chestwall in setting of Marfan Syndrome

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1 Answer
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Radiation Oncology · Beth Israel Deaconess Medical Center
Answered on

There are still substantial uncertainties about the impact of specific risk factors on the local recurrence rate following PBI. A tumor-free margin width of less than 2 mm was associated with a high risk of local failure in a number of studies (Chen et al., PMID 16421922; Vicini et al., PMID 1730693...

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