In a patient with gout previously treated with pegloticase who then discontinued therapy, can pegloticase be safely and effectively restarted?

It depends on the reason for discontinuation of Pegloticase therapy in the first place, since efficacy and safety data varies with it.

Pegloticase can be safely and effectively restarted if the initial discontinuation was not due to a loss of efficacy or a severe infusion reaction, and should be done...