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In a patient with sicca symptoms and SS-B antibodies only, can a minor salivary gland lip biopsy with lymphoid aggregates, but also scattered areas of acute neutrophilic inflammation be consistent with Sjogren's Disease?

2 Answers
Mednet Member
Mednet Member
Rheumatology · Uniformed Services University of the Health Sciences (USUHS)

I agree with @Dr. First Last and cannot speculate on the neutrophils.

I'd also like to point out that a French study showed that only 1% of isolated anti-SSB patients had Sjogren's disease, SjD (Jardel et al., PMID 28931060); all others had other autoimmune diseases, neoplasia, infection, and solitar...

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Mednet Member
Mednet Member
Rheumatology · University of California, Berkeley and San Francisco

Without additional information, it is hard to comment meaningfully. It depends on the number of glands harvested, the amount of glandular tissue available to the pathologist, and where the path was read. It is possible to submit the pathology for a second opinion to groups with expertise in Sjogren'...

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