Topics:
Gynecologic Cancers • Vulvar Cancer
In a patient with squamous vulvar cancer previously treated with cisplatin and radiotherapy and now with widely metastatic recurrence, would you initiate treatment with chemotherapy or consider immunotherapy?
CPS score is pending
Answer from: at Academic Institution
This is a difficult case, and the literature on systemic treatment options in metastatic vulvar cancer is sparse. I would check for PDL1, MMR as you have done. In addition, I would also test for NTRK gene fusion. A next general sequencing panel such as CARIS or Foundation One is useful in these sett...
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Answer from: at Academic Institution
I would wait for the CPS score. If >1, then immunotherapy.
If not - carbo/taxol/bev.