In adults ≥80 years with TSH 6–10 mIU/L and minimal symptoms, do you initiate levothyroxine, monitor, or avoid treatment entirely?  

As always, we do want to provide an individualized approch. Based on the extent of frailty and severity of symptoms, I do offer watchful waiting as an option during the shared decision conversation. TRUST (Thyroid Hormone Replacement for Untreated Older Adults with Subclinical Hypothyroidism) trial ...