In contemplating neoadjuvant RT, how would you manage a large, non-RT-induced angiosarcoma of the right breast in a young female?

I would have her get a mastectomy first.

1. You want your surgeons in their comfort zones. Preop treatment of any sort is a discussion to have with her surgeon in advance of doing anything. Breast surgeons who see 99.9% adenocarcinoma are used to preop chemo but not usually preop radiation.

2. Radi...

Multiple approaches possible. We have tended to offer neoadjuvant radiation therapy as upfront mastectomy can often lead to positive margins.

While different RT techniques exist we have utilized neoadjuvant RT alone (BID or TID) followed by mastectomy. 4 cm around all gross disease. We have start...