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In light of the ROADS data, how are you choosing between intraoperative tile-based radiation therapy (TBRT) and postoperative SRT for newly diagnosed resectable brain metastases?

Weinberg et al., ASCO 2026
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What is the biggest barrier to adopting GammaTile for resected brain metastases in your practice?

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3 Answers
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Radiation Oncology · Icahn School of Medicine at Mount Sinai
Answered on

In light of the ROADS data, I would be cautious about broadly changing practice at this point.

While the local control benefit with cesium-131 GammaTile is impressive and biologically plausible, reported OS is much harder to reconcile. A 26% absolute improvement in 2-year OS from a local therapy int...

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Radiation Oncology · Clearview Cancer Institute
Answered on

Very thoughtful comments from both Dr. @Dr. First Last and Dr. @Dr. First Last, and a helpful perspective on these data.

Interesting data and potentially another useful tool for these patients, but I too am struggling to reconcile the magnitude of the reported OS benefit with the observed difference...

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Radiation Oncology · Columbia University Irving Medical Center
Answered on

The authors should be congratulated for this important study, which helps provide another tool for the treatment of patients with brain metastases.

In light of ROADS, I would consider intraoperative cesium-131 tile-based radiation therapy (TBRT)/GammaTile for appropriately selected patients with new...

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