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In light of the SHAPE trial results, how would you manage a patient with an incidentally diagnosed FIGO IA1 cervical cancer after simple extrafascial hysterectomy/BSO?

No LN dissection was performed as it was for a suspected CIN III. Final pathology showed +LVSI, -margins (>10mm), -parametrial extension, and 1.2mm depth of invasion.
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What would be your adjuvant treatment recommendation for a patient with an incidentally diagnosed FIGO IA1 cervical cancer after simple extrafascial hysterectomy/BSO?

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2 Answers
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Radiation Oncology · University of Kentucky
Answered on

Without question, I would recommend that this patient receive pelvic RT and probably cuff brachytherapy as well. The SHAPE trial (NCT01658930) enrolled "low risk" patients, but they allowed LVSI patients into the trial, even though this is a high risk feature for local recurrence. There were approxi...

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Gynecologic Oncology · Medical University of South Carolina
Answered on

If one uses the mm diagnosis of Stage IA cancer (the previous FIGO staging) then there is a ton of data that shows that hysterectomy is adequate therapy.

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