In patients initiating standard-dose oral isotretinoin for severe nodular acne, do you routinely discontinue all topical prescriptions, or have you co-prescribed clascoterone?

Traditionally, I have discontinued topical medications when starting isotretinoin, mainly for the purpose of decreasing irritation (particularly with regard to benzoyl peroxide and tretinoin). I have not started clascoterone concurrently with isotretinoin, but I think it is a reasonable thing to try...