In patients who have failed 5-ASA and have moderate to severe UC, do you utilize 5-ASA as an adjunct, especially rectal therapy?
In the updated ACG guidelines for ulcerative colitis, they recommend against the use of adjunctive 5-ASA in moderate to severe UC on biologic/small molecule. Rubin et al., The American Journal of Gastroenterology 2025
1 Answer
Mednet MemberInvited Expert
Gastroenterology · Harvard Medical School
Answered on
Good question. There are two separate questions here.
The first is regarding oral 5-ASA therapy. In patients who require initiation of advanced therapy for control of their ulcerative colitis after failing 5-ASA, both the AGA and ACG guidelines for moderate to severe UC recommend not continuing 5-AS...
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