In patients with a history of HIT, how do you counsel them on the use of the AstraZeneca vaccine given reports of unusual thrombosis and association with PF4/heparin antibodies?
AstraZeneca may cause PF4 antibodies leading to vaccine-induced prothrombotic immune thrombocytopenia (VIPIT).
Answer from: at Academic Institution
Until we know more, it seems prudent to avoid the AstraZeneca and J&J vaccines, particularly if there is a history of HIT. The Pfizer and Moderna vaccines use a different technology and have not been associated with the thrombosis/thrombocytopenia syndrome.
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