In patients with advanced HR+, HER2- breast cancer who have progressed on first-line CDK 4/6i and ET and found to have ESR1 mutation, are you offering combination of abemaciclib and elacestrant in the 2nd line or SERD monotherapy?

In my practice, when treating patients with advanced hormone receptor-positive (HR+), HER2-negative breast cancer who have progressed on first-line CDK4/6 inhibitors and endocrine therapy, and who harbor ESR1 mutations, I typically consider elacestrant monotherapy as the preferred second-line treatm...

Until recently, Elacestrant was the drug of choice for patients with HR + and HER2 - metastatic breast cancer with ESR1 mutations who progressed on endocrine and CDK 4/6 inhibitor therapy, based on the EMERALD study.

However, since September 2025, the FDA has approved multiple other drugs that can b...