In patients with depression and a suboptimal response to initial trial of SSRI, do you generally tend to augment (ie, add buspirone, bupropion), switch agents, or increase dose?

What would you do next in patients with depression whose symptoms do not go into remission following 12 weeks of moderate dose SSRI?

• Increase the dose of SSRI
• Change to another SSRI
• Change to an SNRI
• Add on buspirone
• Add on bupropion
• Refer to psychiatry
• Refer for CBT
• Other