In patients with high-risk polycythemia vera with a history of thrombosis, should aspirin be used in addition to indefinite anticoagulation and cytoreduction for prevention of recurrent thrombosis?

Topics: Hematologic Malignancies • Myeloproliferative Neoplasms • Hematology

What if there are no cardiovascular risk factors? Are VKAs preferred or can DOACs be used?

Answer from: Medical Oncologist at Community Practice

I do not continue aspirin in patients who require anticoagulation out of concern for an increased risk of bleeding. In an analysis of the REVEAL database, patients receiving anticoagulation in combination with aspirin were over 4-fold as likely to have a hemorrhage (HR [95% CI] = 4.22 [2.57, 6.94]; ...

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at UT Southwestern Medical Center
Thank you for your time and expertise, Dr. @Aaron ...

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