In patients with lupus nephritis on maintenance therapy, is there additional benefit in utilizing 2 grams vs 3 grams of mycophenolate mofetil (MMF) daily?
Answer from: at Community Practice
I agree with @Gary Gilkeson's answer.
A few nuances to add:
In my patients of African Ancestry, I always start with 1.5 gm bid if tolerated as they tend to need a higher dose (probably related to lower enterohepatic circulation, more rapid mycophenolic acid clearance, and other metabolic mechani...
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Answer from: at Academic Institution
Agree generally with Drs. @Gilkeson and @Thomas with following caveats. First, MMF is used for both induction of remission and maintenance of remission. I too observe that patients of Asian ancestry have high renal CR even at 2 gm a day while patients of African American often demonstrate better red...
Answer from: at Academic Institution
This is an interesting question. My take on it would be if the patient's renal disease activity is well controlled on 2g a day I would stay at that dose. Black lupus nephritis patients often need the higher dose of 3g per day and is the dose I use to treat LN in Black patients. I maintain them on 3g...