In patients with MASLD and F2–F3 fibrosis, would you initiate Resmetirom even if they are not making active lifestyle changes?  

Yes, many patients had an underlying metabolic disorder that is difficult/impossible to address with lifestyle interventions alone and will go on to progress in their liver disease if left alone. Now with the approval of Semaglutide in August 2025 by the FDA and the approval of Resmetirom, we have t...

I would definitely treat with that level of fibrosis. Sometimes, discussing the dangers of progressing fibrosis to cirrhosis without treatment will put the fear of God into them and get them to change their lifestyle.

I would still do it because options are otherwise limited. I may consider GLP-1 more so to affect weight loss if someone is struggling with lifestyle changes. The current approach I am using is using RES for at least 1 year if all is tolerated well. Lifestyle changes would be a plus but not a barrie...