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In patients with persistent knuckle pads refractory to high-potency topical corticosteroids and keratolytics, what procedural or off-label therapies (e.g., intralesional 5-FU, ablative/vascular laser, or surgical debulking) have yielded successful flattening in your practice?

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What do you recommend for patients with persistent knuckle pads refractory to high-potency topical corticosteroids and keratolytics?

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