In patients with resected cutaneous squamous cell carcinoma who lack clear traditional histologic indications for radiation (e.g., negative margins, no large-nerve PNI) but demonstrate a 40-GEP Class 2B high-risk profile, do you routinely recommend adjuvant radiation therapy?

In completely resected, margin-negative, node-negative cSCC without NCCN adjuvant RT indications (large-caliber/named-nerve PNI, LVI, positive margins/unresectable, or bone/skull base invasion), we do not routinely recommend adjuvant RT for a 40-GEP Class 2B result alone. A Class 2B result can be us...