In patients with RET-fusion positive NSCLC with symptomatic brain metastases, would you consider starting selpercatinib/pralsetinib upfront or would you proceed with whole brain radiation with TKI to follow?
Answer from: Medical Oncologist at Academic Institution
In general, my favored approach for a patient with asymptomatic brain metastasis (and nothing scary like big edema, midline shift, bleeding, etc) is brain-penetrating TKI, if available. This applies to EGFR (osi), ALK (alectinib), and RET (I use selpercatinib). Happily, these patients live longer. W...
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Medical Oncologist at Kaiser Permanente What about symptomatic brain mets with vasogenic e...
Medical Oncologist at Cedars-Sinai Medical Center One must use their judgement but if brain metastas...
What about symptomatic brain mets with vasogenic e...
One must use their judgement but if brain metastas...