In patients with Stickler syndrome, would you recommend prophylactic laser to areas of lattice?

There is a growing body of evidence that laser retinopexy in patients with Stickler syndrome significantly reduces the risk of retinal detachment. Up to 60% of patients with Stickler syndrome develop retinal detachment, with those with type 1 and type 2 Stickler syndrome at the highest risk. Extended vitreous base laser treatment reduced the incidence of retinal detachment from 73% to 3%. Another treatment option is 360-degree cryoretinopexy of the vitreous base, with one study showing a reduction in the rate of retinal detachment from 53.6% to 8.3%.

In patients with genetically confirmed Stickler syndrome (especially type 1), laser retinopexy should be strongly considered, even in the absence of lattice degeneration.