In the treatment of osteoarthritis with low-dose radiation therapy is there data to support the claim that LDRT does not limit or preclude later orthopedic surgery?

At LDRT doses, the biological effects are anti-inflammatory and immunomodulatory rather than cytotoxic or fibrogenic, and there is no evidence of vascular injury, impaired cellular proliferation, or tissue destruction. Animal models and cellular studies provide robust evidence that LDRT at OA releva...

Completely agree with Dr. @Dr. First Last above. From a clinical and theoretical perspective, as radiation oncologists, we would all readily agree that there is no reason to be concerned about the impact of 3-6 Gy on wound healing or surgical complications.

However, effectively communicating this re...

To my knowledge, there is no data assessing the feasibility of joint replacement or other orthopedic procedures after low-dose radiation therapy. Extrapolating from the management of malignant disease, however, orthopedic surgeons do have experience operating after delivery of much higher doses used...