In what cases do you use baclofen for alcohol use disorder?

As Dr. @Dr. First Last mentioned, it's generally not a first-line choice (at least in the US). It is much more popular in Europe, but efficacy usually comes at notably higher doses. In one case series from 144 patients treated with baclofen in a French clinic, the mean maximum dose was 211 mg daily ...

Although some studies suggest that baclofen is superior to a placebo for treating alcohol use disorder, it is not listed as a recommended or suggested medication in the practice guidelines of the American Psychiatric Association or the VA/DoD Clinical Practice Guidelines. In clinical practice, baclo...

I would feel very much comfortable prescribing that medication. If I would like to change the GABA/glutamate ratio, I definitely would go for the acamprosate. Every medicine that has words "exact mechanism of action is not known" in the PDR is causing goosebumps on my skin.

We do have quite a signif...