Topics:
Non-malignant Disease • Pediatric Oncology • Medical Oncology • Hematology • Benign Hematology • HLH • Neutropenia
In what circumstances would you give G-CSF to a patient with severe neutropenia and HLH?
Answer from: at Academic Institution
I am not aware of any direct clinical evidence that addresses this question. That said, I would be very reluctant to treat with G-CSF in the setting of HLH. G-CSF is an inflammatory cytokine that might aggravate HLH. Moreover, since the mechanism of neutropenia in HLH is thought to be increased neut...
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