In what clinical scenario would you consider the use of budesonide over prednisone as part of the pharmacologic management of autoimmune hepatitis?
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Mednet MemberInvited Expert
Hepatology · UC San Diego Health
Answered on · Updated on
Primarily in patients where the side effects of prednisone will or are too difficult to tolerate (diabetics, weight gain, metabolic syndrome, psychiatric disease, etc). I like to try prednisone first because of its ability to elucidate a biochemical response, fairly rapidly, so we know what we are dealing with. But I will switch over to budesonide if compliance with prednisone is becoming an issue, as long as the patient doesn't have advanced fibrosis/cirrhosis.
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