In which clinical scenarios would you prefer to sequence chemotherapy prior to radiation therapy in total neoadjuvant therapy for locally advanced rectal cancer?   

Are there clinical scenarios in which you have found chemotherapy first has been beneficial? 

(i.e., advanced T stage, extra-mesorectal LN, anatomical constraints, near obstruction, etc)

Answer from: Medical Oncologist at Community Practice
Radiation Oncologist at Fox Chase Cancer Center
I agree with Dr. @Michael Shusterman. We generally...
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