In which clinical scenarios would you prefer to sequence chemotherapy prior to radiation therapy in total neoadjuvant therapy for locally advanced rectal cancer?
Are there clinical scenarios in which you have found chemotherapy first has been beneficial?
(i.e., advanced T stage, extra-mesorectal LN, anatomical constraints, near obstruction, etc)
1 Answer
Mednet MemberInvited Expert
Medical Oncology · NYU Long Island School of Medicine
Answered on · Updated on
Our institutional preference has been to use long course chemoradiotherapy prior to chemotherapy due to the enhanced clinical response rate. The exceptions have been for patients with obstructive physiology, where chemotherapy first can potentially generate a safer and more rapid response. Chemother...
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