In which patients will you consider a shorter course of adjuvant Herceptin?

At this point, I would not treat any patients with short term trastuzumab. The Short-Her study had very wide confidence intervals for non-inferiority, and there was a numerically superior 2.2% improvement in DFS in the long (standard) trastuzumab arm. Additionally, in the patients with the worst pro...

I agree with @Dr. First Last. Notably, the FinHer adjuvant chemo+/- trastuzumab study evaluated the impact of chemotherapy with or without only 9 weeks of trastuzumab and demonstrated hazard ratios similar to those reported in other studies. However, one year of trastuzumab has remained the standard...