Is 60 Gy in 40 fractions BID an appropriate regimen to use for LS-SCLC now?   

The recent randomized Phase II Scandinavian trial (Gronberg et al.) showed a statistically significant increased 2-year and median overall survival in small cell lung cancer patients treated with high dose BID radiation (60 Gy in 40 fractions) as compared to standard dose BID radiation (45 Gy in 30 fractions). There was also no increase in toxicity with the higher dose.

Has anyone here used this high dose 60 Gy BID regimen? Would you consider it a reasonable regimen to use off protocol?



Answer from: Radiation Oncologist at Academic Institution

Answer from: Radiation Oncologist at Community Practice
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Radiation Oncologist at Northeast Alabama Regional Medical Center
At the end of the day, it's an extra week of treat...
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Answer from: Radiation Oncologist at Academic Institution

Answer from: Radiation Oncologist at Community Practice
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Radiation Oncologist at Florida Inst. of Research
Not to mention providing another option, with appr...
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Answer from: Radiation Oncologist at Community Practice

Answer from: Radiation Oncologist at Academic Institution