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Would you consider single dose benzathine penicillin G for treatment of latent syphilis of unknown duration based on recent observational data suggesting non-inferiority of one vs three doses for management of all stages of syphilis, as well as to mitigate issues with adherence, poor follow up, and drug shortage?
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Mednet Member
Infectious Disease · University of Washington Center for AIDS and STD
Yes. I would now consider a single dose of benzathine penicillin G the treatment of choice for all asymptomatic late syphilis in addition to primary, secondary, and latent syphilis under a year in duration. The 3-dose BPG recommendation always was pretty much data-free, an echo of the early days of ...