Is APBI appropriate in post menopausal women with small, triple negative breast cancers excised with negative margins?
Answer from: Radiation Oncologist at Community Practice
We do have data to suggest that these patients do poorly with mastectomy alone vs other t1/t2 patients: Wang et al., PMID 21852010 Abdulkarim et al., PMID 21670451 Extrapolating from that, biologically, these seem to be more aggressive both locoregionally (despite mastectomy/removal o...
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Answer from: Radiation Oncologist at Community Practice
I haven't done PBI for TNBC, mostly based on institutional series. Local recurrence was 20% at 5 years on the Wisconsin series (Cannon et al., PMID 23709055) and 33% at 5 years on the MGH series (Pashtan et al., PMID 22652104). I would consent patients with these numbers as possible outcomes b...
Comments
Radiation Oncologist at Lake Huron Medical Center
Interesting - the MGH series had just 9 triple neg...
Interesting - the MGH series had just 9 triple neg...
Radiation Oncologist at SwedishAmerican Regional Cancer Center
Yep. These are all fair points. And I do not know ...
Yep. These are all fair points. And I do not know ...
Radiation Oncologist at Lake Huron Medical Center
These are very valuable comments and I would say I...
These are very valuable comments and I would say I...
Radiation Oncologist at Texas Oncology-Arlington Cancer Center North
If you use the FAST-Foward regimen, what dose do y...
If you use the FAST-Foward regimen, what dose do y...
Answer from: Radiation Oncologist at Community Practice
I'm not sure histological type or receptor status predicts where the tumor is likely to fail. My presumption is that triple negative tumors would have a higher recurrence rate - not that they would recur more likely outside the cavity. The past "suitability" criteria did not list a reference showing...