Topics:
Pediatric Oncology • Thoracic Malignancies • Medical Oncology • Drug Eruptions • General Dermatology
Is cross reactivity low enough to try cisplatin as an alternative for patients who experience hypersensitivity reaction to carboplatin?
Is skin testing advised prior to trialing alternative?
Answer from: Medical Oncologist at Academic Institution
A couple of preparatory comments. First, there is a reasonable review recently published about platinum sensitivity and management questions related to this (Makrilia et al., PMID 20886011). The second comment is that platinum sensitivity reactions can be quite severe, and are relatively rare with &...
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Answer from: Medical Oncologist at Academic Institution
Cross-reactivity between cisplatin and other platinum salts seems low. I replaced carbo or oxaliplatin with cisplatin several times without any testing or issues. Pasteur et al., PMID 30776524.