Is cross reactivity low enough to try cisplatin as an alternative for patients who experience hypersensitivity reaction to carboplatin?
Is skin testing advised prior to trialing alternative?
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What treatment would you offer for a patient who would benefit from further cisplatin or carboplatin therapy and had a severe hypersensitivity reaction to carboplatin?
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2 Answers
Mednet MemberInvited Expert
Medical Oncology · Wexner Medical Center at The Ohio State University
Answered on
A couple of preparatory comments. First, there is a reasonable review recently published about platinum sensitivity and management questions related to this (Makrilia et al., PMID 20886011). The second comment is that platinum sensitivity reactions can be quite severe, and are relatively rare with <...
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Mednet Member
Medical Oncology · Henry Ford Health System
Answered on
Cross-reactivity between cisplatin and other platinum salts seems low. I replaced carbo or oxaliplatin with cisplatin several times without any testing or issues.
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