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Is extensive abutment of the duodenum without invasion a contraindication to SBRT for pancreatic tumors?

If so, how do you quantify this when making a decision about who may or may not be a candidate for SBRT?
1 Answer
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Radiation Oncology · Memorial Sloan-Kettering Cancer Center
Answered on · Updated on

First, let's be clear that we are talking about a palliative (or neoadjuvant) dose of radiation (53Gy BED). A similar dose, 54Gy in 30 fx, failed to improved overall survival in a randomized phase III trial (LAP07). Next, let's consider one of the most fundamental principles in radiotherapy, fractio...

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