Is history of radiation an absolute contraindication to using parathyroid hormone (PTH) analogues?
4
3 AnswersMednet Member
Rheumatology · U of AZ Phoenix Dept of Orthopaedics
Hx of prior radiation was never a contraindication, it was a warning due to the known increase in osteosarcoma in patients who had prior radiation. A contraindication requires proof of harm. There was no data that radiation plus a PTH anabolic increased the risk of osteosarcoma. With the review of 1...
Mednet Member
Rheumatology · Hudson Hospital & Clinic
I believe past history of radiation is indeed one of the contraindications listed. Though this is largely based on theoretical concerns of increased risk of bony cancer in animal studies. I am not aware of any large set of human data that actually addresses this issue.