Is it acceptable to use SBRT for prostate bed RT?

In my opinion, this should not be done outside of an IRB-approved research study. We are beginning to see some published experience with moderate hypofractionation in post-prostatectomy patients, which would indicate, at least preliminarily, that this approach may be safe, although the optimal dose ...

No

As the first author on one of the toxicity analyses of one of the trials in this space, I would not recommend prostate bed SBRT for salvage RT off-protocol at the current time.

Yes, prostate bed SBRT reirradiation is reasonable under certain highly selected cases, preferably on protocol and with pathological confirmation, after informed signed consent.