Is it appropriate to offer definitive trimodality therapy, as an equivalent option to neoadjuvant chemotherapy followed by radical cystectomy, in patients with muscle-invasive bladder cancer regardless of fitness or platinum eligibility?

Topics: Radiation Oncology • Genitourinary Cancers • Bladder Cancer • Medical Oncology • Urology • Urologic Oncology

Has this recent retrospective analysis published in Lancet Oncology changed your practice?

Answer from: Radiation Oncologist at Academic Institution

There are now several retrospective studies utilizing advanced statistical techniques suggesting that outcomes after trimodality therapy (TMT) are very similar to those after surgery (e.g., Zlotta et al., PMID 37187202, Brück et al., PMID 37517601, and Kulkarni et al., PMID 28410011). These fin...

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Radiation Oncologist at Duke University Health System
Another relevant resource here is a paper we wrote...

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