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Is it reasonable to tell patients that Evenity lowers fracture risk by about 70%, while Prolia reduces it by around 50%?

1 Answer
Mednet MemberInvited Expert
Endocrinology · Boston University School of Medicine
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It depends on the skeletal site. A 3-year fracture relative risk reduction study of Prolia versus placebo revealed a 68% reduction in new vertebral fractures, a 40% reduction in hip fractures, and a 20% reduction in nonvertebral fractures. (Cummings et al., PMID 19671655) The relative risk of new vertebral fractures in a study comparing Eventity with placebo reported a 73% relative risk reduction of a new vertebral fracture at month 12 and 75% relative risk reduction at 24 months. What I believe...

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