Is it safe to give thoracic irradiation to a patient with lung cancer previously treated with a VEGF inhibitor?

We did a study in patients getting VEGF inhibitors and SBRT. Anecdotally we had seen some impressive (small bowel necrosis requiring surgery) and unpredicted toxicity and we were looking for a common factor that tied them together. VEGF inhibition was that common factor. These are all patients treated with SBRT in the abdomen but the grade 3+ tox for patients that got bev during or in a period of 3 mon following was 38% vs none in patients with no vegf (http://www.ncbi.nlm.nih.gov/pubmed/23920388). Kinda concerin'. In all these patients we held to the TG 101 constraints for bowel. Noteable is that all the patients received the bev (and 1 patient with sorafenib) had the drug after the RT was done. I think the theory is the vegf inhibition bl...